北京手足癣医院电话 http://pf.39.net/bdfyy/bdfyw/index.htmlPaperReading
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TOXregulatesgrowth,DNArepair,andgenomicinstabilityinT-cellAcuteLymphoblasticLeukemia
RiadhLobbardi,GrahamDellaire,DavidM.Langenau,etal.
哈佛医医院
CancerDiscov.
TherearesomedominantoncogenicdriversinhumanT-cellacutelymphoblasticleukemia(T-ALL).Inthispaper,theauthorsprovidedaplausiblecellularmechanismforelevatedgenomicDNAaberrationsobservedinhumanT-ALLandrevealedtherolesofTOXinregulatingNon-HomologousEndJoiningrepair(NHEJ).First,theyusedthezebrafishtransgenicMYC-inducedT-ALLmodeltoidentifygenesthatcollaboratewithMYCtoacceleratetimetoT-ALLonset.TOXsynergizedwithMYCwasfoundtohaveprominentrolesintransformingearlythymicprecursorcellsandactsbyexpandingtheoverallpooloftransformedclonesatleukemiainitiation.QuantitativechangesinDNAcontentandlow-passwholegenomesequencing(WGS)confirmedthatTOXimpartedelevatedgenomicinstabilityinzebrafishMyc-inducedT-ALL.TOXwastransfectedintomouseembryonicfibroblasts(MEF)cellsandchromosomalabnormalitieswerefoundbymetaphasespread.Further,TOXisexpressedinamajorityofhumanT-ALLandisregulatedbytheTAL1/MYBtranscriptional
